Publications

Hong Kong Osteoporosis Study

2017

  • Cheung CL*(*Corresponding author), Tan KCB, Kung AWC (2017) Cohort Profile: The Hong Kong Osteoporosis Study and the Follow-Up Study. Int J Epiemiology (Accepted)
  • Leung RYH, Cheung BMY, Nguyen US, Kung AWC, Tan KCB, Cheung CL* (*Corresponding author). (2017) Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese. Bone;97:293-298
  • Leung RYH, Han Y, Sing CW, Cheung BMY, Wong ICK, Tan KCB, Kung AWC, Cheung CL* (*Corresponding author). (2017) Serum 25-Hydroxyvitamin D and the risk of stroke in Hong Kong Chinese. Thrombosis and Haemostasis;117(1):158-163

2016

  • Sing CW, Cheng VK, Ho DK, Kung AW, Cheung BM, Wong IC, Tan KC, Salas-Salvado J, Becerra-Tomas N, and Cheung CL*(*Corresponding author) (2016). Serum calcium and incident diabetes: an observational study and meta-analysis. Osteoporosis international 27, 1747-1754.

2014

  • Moayyeri A, Hsu YH, Karasik D, Estrada K, Xiao SM, Nielson C, Srikanth P, Giroux S, Wilson SG, Zheng HF, et al. (2014). Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Human molecular genetics 23, 3054-3068.
  • Kwan, J.S., Hsu, Y.H., Cheung, C.L., Dupuis, J., Saint-Pierre, A., Eriksson, J., Handelman, S.K., Aragaki, A., Karasik, D., Pramstaller, P.P., et al. (2014). Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. Human molecular genetics 23, 6684-6693.
  • Cheung, E., Kung, A.W., and Tan, K.C. (2014). Outcomes of applying the NOF, NOGG and Taiwanese guidelines to a cohort of Chinese early postmenopausal women. Clinical endocrinology 80, 200-207.
  • Cheung, E., Cheung, C.L., Kung, A.W., and Tan, K.C. (2014). Possible FRAX-based intervention thresholds for a cohort of Chinese postmenopausal women. Osteoporosis international 25, 1017-1023.
  • Cheung, E., Bow, C., Loong, C., Lee, K.K., Ho, A.Y., Soong, C., Chan, Y.Y., Tan, K.C., and Kung, A.W. (2014). A secular increase in BMD in Chinese women. Journal of bone and mineral metabolism 32, 48-55.

2013

  • Xiao, S.M., Kung, A.W., Sham, P.C., and Tan, K.C. (2013). Genetic analysis of recently identified osteoporosis susceptibility genes in southern Chinese. The Journal of clinical endocrinology and metabolism 98, E1827-1834.
  • Cheung, C.L., Nguyen, U.S., Au, E., Tan, K.C., and Kung, A.W. (2013). Association of handgrip strength with chronic diseases and multimorbidity: a cross-sectional study. Age 35, 929-941.
  • Cheung, C.L., Lau, K.S., Sham, P.C., Tan, K.C., and Kung, A.W. (2013). Genetic variants in GREM2 are associated with bone mineral density in a southern Chinese population. The Journal of clinical endocrinology and metabolism 98, E1557-1561.
  • Cheung, C.L., Lau, K.S., Sham, P.C., Tan, K.C., and Kung, A.W. (2013). Genetic variant in vitamin D binding protein is associated with serum 25-hydroxyvitamin D and vitamin D insufficiency in southern Chinese. Journal of human genetics 58, 749-751.
  • Kung, A.W., Fan, T., Xu, L., Xia, W.B., Park, I.H., Kim, H.S., Chan, S.P., Lee, J.K., Koh, L., Soong, Y.K., et al. (2013). Factors influencing diagnosis and treatment of osteoporosis after a fragility fracture among postmenopausal women in Asian countries: a retrospective study. BMC women's health 13, 7.

2012

  • Xiao, S.M., Kung, A.W., Gao, Y., Lau, K.S., Ma, A., Zhang, Z.L., Liu, J.M., Xia, W., He, J.W., Zhao, L., et al. (2012). Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density. Human molecular genetics 21, 1648-1657.
  • Xiao, S.M., Gao, Y., Cheung, C.L., Bow, C.H., Lau, K.S., Sham, P.C., Tan, K.C., and Kung, A.W. (2012). Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk. Osteoporosis international 23, 1877-1887.
  • Liu, C.T., Estrada, K., Yerges-Armstrong, L.M., Amin, N., Evangelou, E., Li, G., Minster, R.L., Carless, M.A., Kammerer, C.M., Oei, L., et al. (2012). Assessment of gene-by-sex interaction effect on bone mineral density. Journal of bone and mineral research 27, 2051-2064.
  • Estrada, K., Styrkarsdottir, U., Evangelou, E., Hsu, Y.H., Duncan, E.L., Ntzani, E.E., Oei, L., Albagha, O.M., Amin, N., Kemp, J.P., et al. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature genetics 44, 491-501.
  • Cheung, C.L., Tan, K.C., Bow, C.H., Soong, C.S., Loong, C.H., and Kung, A.W. (2012). Low handgrip strength is a predictor of osteoporotic fractures: cross-sectional and prospective evidence from the Hong Kong Osteoporosis Study. Age 34, 1239-1248.
  • Cheung, C.L., Sham, P.C., Xiao, S.M., Bow, C.H., and Kung, A.W. (2012). Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects. Osteoporosis international 23, 131-142.
  • Bow, C.H., Cheung, E., Cheung, C.L., Xiao, S.M., Loong, C., Soong, C., Tan, K.C., Luckey, M.M., Cauley, J.A., Fujiwara, S., et al. (2012). Ethnic difference of clinical vertebral fracture risk. Osteoporosis international 23, 879-885.
  • Cheung, E.Y., Bow, C.H., Cheung, C.L., Soong, C., Yeung, S., Loong, C., and Kung, A. (2012). Discriminative value of FRAX for fracture prediction in a cohort of Chinese postmenopausal women. Osteoporosis international 23, 871-878.

2011

  • Tsang, S.W., Bow, C.H., Chu, E.Y., Yeung, S.C., Soong, C.C., and Kung, A.W. (2011). Clinical risk factor assessment had better discriminative ability than bone mineral density in identifying subjects with vertebral fracture. Osteoporosis international 22, 667-674.
  • Li, G.H., Deng, H.W., Kung, A.W., and Huang, Q.Y. (2011). Identification of genes for bone mineral density variation by computational disease gene identification strategy. Journal of bone and mineral metabolism 29, 709-716.
  • Li, G.H., Cheung, C.L., Xiao, S.M., Lau, K.S., Gao, Y., Bow, C.H., Huang, Q.Y., Sham, P.C., and Kung, A.W. (2011). Identification of QTL genes for BMD variation using both linkage and gene-based association approaches. Human genetics 130, 539-546.
  • Kwan, J.S., Xiao, S., Bow, C., Cheung, C.L., Soong, C., Lau, K.S., Sham, P.C., and Kung, A.W. (2011). Heritability of serum osteoprotegerin. Annals of human genetics 75, 584-588.
  • Kwan, J.S., Kung, A.W., and Sham, P.C. (2011). A simple bias correction in linear regression for quantitative trait association under two-tail extreme selection. Behavior genetics 41, 776-779.
  • Cheung, E., Tsang, S., Bow, C., Soong, C., Yeung, S., Loong, C., Cheung, C.L., Kan, A., Lo, S., Tam, S., et al. (2011). Bone loss during menopausal transition among southern Chinese women. Maturitas 69, 50-56.
  • Bow, C.H., Tsang, S.W., Loong, C.H., Soong, C.S., Yeung, S.C., and Kung, A.W. (2011). Bone mineral density enhances use of clinical risk factors in predicting ten-year risk of osteoporotic fractures in Chinese men: the Hong Kong Osteoporosis Study. Osteoporosis international 22, 2799-2807.

2010

  • Styrkarsdottir, U., Halldorsson, B.V., Gudbjartsson, D.F., Tang, N.L., Koh, J.M., Xiao, S.M., Kwok, T.C., Kim, G.S., Chan, J.C., Cherny, S., et al. (2010). European bone mineral density loci are also associated with BMD in East-Asian populations. PloS one 5, e13217.
  • Li, G.H., Kung, A.W., and Huang, Q.Y. (2010). Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women. Osteoporosis international 21, 1009-1020.
  • Kung, A.W., Xiao, S.M., Cherny, S., Li, G.H., Gao, Y., Tso, G., Lau, K.S., Luk, K.D., Liu, J.M., Cui, B., et al. (2010). Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. American journal of human genetics 86, 229-239.
  • Cheung, C.L., Xiao, S.M., and Kung, A.W. (2010). Genetic epidemiology of age-related osteoporosis and its clinical applications. Nature reviews Rheumatology 6, 507-517.

2009

  • Tsang, S.W., Kung, A.W., Kanis, J.A., Johansson, H., and Oden, A. (2009). Ten-year fracture probability in Hong Kong Southern Chinese according to age and BMD femoral neck T-scores. Osteoporosis international 20, 1939-1945.
  • Tang, P.L., Cheung, C.L., Sham, P.C., McClurg, P., Lee, B., Chan, S.Y., Smith, D.K., Tanner, J.A., Su, A.I., Cheah, K.S., et al. (2009). Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women. Journal of bone and mineral research 24, 1013-1021.
  • Ngai, H.H., Cheung, C.L., Yao, T.J., and Kung, A.W. (2009). Bioimpedance: can its addition to simple clinical criteria enhance the diagnosis of osteoporosis? Journal of bone and mineral metabolism 27, 372-378.
  • Kwan, J.S., Cherny, S.S., Kung, A.W., and Sham, P.C. (2009). Novel sib pair selection strategy increases power in quantitative association analysis. Behavior genetics 39, 571-579.
  • Huang, Q.Y., Li, G.H., and Kung, A.W. (2009). The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis. Bone 45, 289-294.
  • Huang, Q.Y., Li, G.H., and Kung, A.W. (2009). Multiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese. Bone 44, 984-988.
  • Cheung, C.L., Chan, B.Y., Chan, V., Ikegawa, S., Kou, I., Ngai, H., Smith, D., Luk, K.D., Huang, Q.Y., Mori, S., et al. (2009). Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. Human molecular genetics 18, 679-687.

2008

  • Lim, S.K., Kung, A.W., Sompongse, S., Soontrapa, S., and Tsai, K.S. (2008). Vitamin D inadequacy in postmenopausal women in Eastern Asia. Current medical research and opinion 24, 99-106.
  • Lai, B.M., Cheung, C.L., Luk, K.D., and Kung, A.W. (2008). Estrogen receptor alpha CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women. Osteoporosis international 19, 571-579.
  • Huang, Q.Y., Li, G.H., Cheung, W.M., Song, Y.Q., and Kung, A.W. (2008). Prediction of osteoporosis candidate genes by computational disease-gene identification strategy. Journal of human genetics 53, 644-655.
  • Cheung, C.L., Sham, P.C., Chan, V., Paterson, A.D., Luk, K.D., and Kung, A.W. (2008). Identification of LTBP2 on chromosome 14q as a novel candidate gene for bone mineral density variation and fracture risk association. The Journal of clinical endocrinology and metabolism 93, 4448-4455.
  • Cheung, C.L., Huang, Q.Y., Chan, V., and Kung, A.W. (2008). Association of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women. Human heredity 65, 232-239.
  • Cheung, C.L., Chan, V., and Kung, A.W. (2008). A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women. Human heredity 65, 1-8.

2007

  • Wat, W.Z., Leung, J.Y., Tam, S., and Kung, A.W. (2007). Prevalence and impact of vitamin D insufficiency in southern Chinese adults. Annals of nutrition & metabolism 51, 59-64.
  • Kung, A.W., Lee, K.K., Ho, A.Y., Tang, G., and Luk, K.D. (2007). Ten-year risk of osteoporotic fractures in postmenopausal Chinese women according to clinical risk factors and BMD T-scores: a prospective study. Journal of bone and mineral research 22, 1080-1087.
  • Kung, A.W., and Huang, Q.Y. (2007). Genetic and environmental determinants of osteoporosis. Journal of musculoskeletal & neuronal interactions 7, 26-32.
  • Ioannidis, J.P., Ng, M.Y., Sham, P.C., Zintzaras, E., Lewis, C.M., Deng, H.W., Econs, M.J., Karasik, D., Devoto, M., Kammerer, C.M., et al. (2007). Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass. Journal of bone and mineral research 22, 173-183.
  • Huang, Q.Y., and Kung, A.W. (2007). The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population. Journal of human genetics 52, 757-762.

2006

  • Ng, M.Y., Sham, P.C., Paterson, A.D., Chan, V., and Kung, A.W. (2006). Effect of environmental factors and gender on the heritability of bone mineral density and bone size. Annals of human genetics 70, 428-438.
  • Lau, H.H., Ng, M.Y., Cheung, W.M., Paterson, A.D., Sham, P.C., Luk, K.D., Chan, V., and Kung, A.W. (2006). Assessment of linkage and association of 13 genetic loci with bone mineral density. Journal of bone and mineral metabolism 24, 226-234.
  • Kung, A.W., and Lee, K.K. (2006). Knowledge of vitamin D and perceptions and attitudes toward sunlight among Chinese middle-aged and elderly women: a population survey in Hong Kong. BMC public health 6, 226.
  • Kung, A.W., Lai, B.M., Ng, M.Y., Chan, V., and Sham, P.C. (2006). T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures. Bone 39, 1097-1106.
  • Huang, Q.Y., Ng, M.Y., Cheung, C.L., Chan, V., Sham, P.C., and Kung, A.W. (2006). Identification of two sex-specific quantitative trait loci in chromosome 11q for hip bone mineral density in Chinese. Human heredity 61, 237-243.
  • Huang, Q.Y., and Kung, A.W. (2006). Genetics of osteoporosis. Molecular genetics and metabolism 88, 295-306.
  • Cheung, W.M., Jin, L.Y., Smith, D.K., Cheung, P.T., Kwan, E.Y., Low, L., and Kung, A.W. (2006). A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene. Bone 39, 470-476.
  • Cheung, C.L., Huang, Q.Y., Ng, M.Y., Chan, V., Sham, P.C., and Kung, A.W. (2006). Confirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese. Human genetics 120, 354-359.

2005

  • Lau, H.H., Ng, M.Y., Ho, A.Y., Luk, K.D., and Kung, A.W. (2005). Genetic and environmental determinants of bone mineral density in Chinese women. Bone 36, 700-709.
  • Kung, A.W., Ho, A.Y., Ross, P.D., and Reginster, J.Y. (2005). Development of a clinical assessment tool in identifying Asian men with low bone mineral density and comparison of its usefulness to quantitative bone ultrasound. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 16, 849-855.
  • Ho, A.Y., and Kung, A.W. (2005). Determinants of peak bone mineral density and bone area in young women. Journal of bone and mineral metabolism 23, 470-475.
  • Cheung, E.Y., Ho, A.Y., Lam, K.F., Tam, S., and Kung, A.W. (2005). Determinants of bone mineral density in Chinese men. Osteoporosis international 16, 1481-1486.

2004

  • Lau, H.H., Ho, A.Y., Luk, K.D., and Kung, A.W. (2004). Transforming growth factor-beta1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern Chinese women. Calcified tissue international 74, 516-521.

2003

  • Kung, A.W., Ho, A.Y., Sedrine, W.B., Reginster, J.Y., and Ross, P.D. (2003). Comparison of a simple clinical risk index and quantitative bone ultrasound for identifying women at increased risk of osteoporosis. Osteoporosis international 14, 716-721.

2002

  • Lau, H.H., Ho, A.Y., Luk, K.D., and Kung, A.W. (2002). Estrogen receptor beta gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women. Bone 31, 276-281.

2001

  • Mei, J., Yeung, S.S., and Kung, A.W. (2001). High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. The Journal of clinical endocrinology and metabolism 86, 5217-5221.
  • Lambrinoudaki, I., and Kung, A.W. (2001). Absence of high-risk "s" allele associated with osteoporosis at the intronic SP1 binding-site of collagen Ialpha1 gene in Southern Chinese. Journal of endocrinological investigation 24, 499-502.
  • Koh, L.K., Sedrine, W.B., Torralba, T.P., Kung, A., Fujiwara, S., Chan, S.P., Huang, Q.R., Rajatanavin, R., Tsai, K.S., Park, H.M., et al. (2001). A simple tool to identify asian women at increased risk of osteoporosis. Osteoporosis international 12, 699-705.
  • He, M., Tan, K.C., Li, E.T., and Kung, A.W. (2001). Body fat determination by dual energy X-ray absorptiometry and its relation to body mass index and waist circumference in Hong Kong Chinese. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 25, 748-752.

2000

  • Ho, A.Y., Yeung, S.S., and Kung, A.W. (2000). PvuII polymorphisms of the estrogen receptor alpha and bone mineral density in healthy southern Chinese women. Calcified tissue international 66, 405-408.

1999

  • Kung, A.W., Tang, G.W., Luk, K.D., and Chu, L.W. (1999). Evaluation of a new calcaneal quantitative ultrasound system and determination of normative ultrasound values in southern Chinese women. Osteoporosis international 9, 312-317.
  • Kung, A.W., Luk, K.D., Chu, L.W., and Tang, G.W. (1999). Quantitative ultrasound and symptomatic vertebral fracture risk in Chinese women. Osteoporosis international 10, 456-461.

1998

  • Kung, A.W., Yeung, S.S., and Lau, K.S. (1998). Vitamin D receptor gene polymorphisms and peak bone mass in southern Chinese women. Bone 22, 389-393.

Thyroid Study

2016

  • Cheung, C.L., Sing, C.W., Tang, C.S., Cheng, V.K., Pirmohamed, M., Choi, C.H., Hung, C.S., Lau, E.Y., Lee, K.F., Mak, M.W., et al. (2016). HLA-B*38:02:01 predicts carbimazole/methimazole-induced agranulocytosis. Clinical pharmacology and therapeutics 99, 555-561.

2012

  • Cheung, C.L., Lau, K.S., Ho, A.Y., Lee, K.K., Tiu, S.C., Lau, E.Y., Leung, J., Tsang, M.W., Chan, K.W., Yeung, C.Y., et al. (2012). Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3. Nature genetics 44, 1026-1029.

Other Studies

2017

  • Sing CW, Wong ICK, Cheung BMY, Chan JCY, Chu JKP, Cheung CL* (*Corresponding author), (2017) Incidence and Risk Estimate of Drug-Induced Agranulocytosis in Hong Kong Chinese. A Population-Based Case-Control Study. Pharmacoepidemiology and Drug Safety (Accepted)
  • Cheung CL, Ho DKC, Sing CW, Tsoi MF, Cheng VKF, Lee GKY, Ho YN, Cheung BMY. (2017) Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese. Scientific Reports;7:41084
  • Lau WCY, Chan EW, Cheung CL, Sing CW, Man KKC, Lip GYH, Siu CW, Lam JKY, Lee ACH, Wong IC. (2017) Association between Dabigatran versus Warfarin and Risk of Osteoporotic Fractures among Patients with Nonvalvular Atrial Fibrillation. JAMA;317:1151-1158

2016

  • Cheung, C.L., Lam, K.S., and Cheung, B.M. (2016). Diabetes is associated with increased risks of low lean mass and slow gait speed when peripheral artery disease is present. Journal of diabetes and its complications 30, 306-311.

2015

  • Cheung, C.L., Sahni, S., Cheung, B.M., Sing, C.W., and Wong, I.C. (2015). Vitamin K intake and mortality in people with chronic kidney disease from NHANES III. Clinical nutrition 34, 235-240.

2014

  • Wong, H.K., Ong, K.L., Cheung, C.L., and Cheung, B.M. (2014). Utilization of glucose, blood pressure, and lipid lowering medications among people with type II diabetes in the United States, 1999-2010. Annals of epidemiology 24, 516-521 e511.
  • Li, C., Cheung, C.L., Cheung, T.T., Samaranayake, N.R., and Cheung, B.M. (2014). Hay fever and hypertension in the US adult population. Clinical and experimental hypertension 36, 206-210.
  • Cheung, C.L., Lam, K.S., Wong, I.C., and Cheung, B.M. (2014). Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA. BMC medicine 12, 154.

2013

  • Cheung, C.L., Tan, K.C., Lam, K.S., and Cheung, B.M. (2013). The relationship between glucose metabolism, metabolic syndrome, and bone-specific alkaline phosphatase: a structural equation modeling approach. The Journal of clinical endocrinology and metabolism 98, 3856-3863.
  • Cheung, C.L., Lam, K.S., and Cheung, B.M. (2013). Serum beta-2 microglobulin predicts mortality in people with diabetes. European journal of endocrinology 169, 1-7.
  • Cheung, C.L., Lam, K.S., and Cheung, B.M. (2013). Serum beta-2 microglobulin concentration predicts cardiovascular and all-cause mortality. International journal of cardiology 168, 4811-4813.
  • Cheung, C.L., Cheung, T.T., Lam, K.S., and Cheung, B.M. (2013). High ferritin and low transferrin saturation are associated with pre-diabetes among a national representative sample of U.S. adults. Clinical nutrition 32, 1055-1060.
  • Cheung, C.L., Cheung, T.T., Lam, K.S., and Cheung, B.M. (2013). Reduced serum beta-trace protein is associated with metabolic syndrome. Atherosclerosis 227, 404-407.